pentobarbital will minimize the extent or outcome of saxagliptin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.pentobarbital will minimize the level or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib